{"id":2,"date":"2019-04-25T12:16:58","date_gmt":"2019-04-25T04:16:58","guid":{"rendered":"http:\/\/149.129.75.225\/?page_id=2"},"modified":"2026-09-16T11:11:18","modified_gmt":"2026-09-16T03:11:18","slug":"publications","status":"publish","type":"page","link":"http:\/\/www.junhaohulab.cn\/index.php\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\t\t
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2026<\/span><\/p>\n

Fang Y, Shen Q, Lin Y, Zhu J, Zhu X, Huang R, Wu Y, Shen F, Li Q, Zheng G, Zhang Z, Chu Q#, Hu J<\/u>#, Shen J#. PARPi combining nanoparticle LIN28B siRNA for the management of malignant ascites<\/b>. Advanced Science,<\/i> e10547, (2026).<\/span><\/p>\n

Luo M, Kou T, Yin Y, Zhou S, Zhu X, Zeng X, Hu J<\/u>, Zhu ZJ.<\/i> Deep-coverage single-cell metabolomics enabled by ion mobility-resolved mass cytometry<\/b>. Nat. Methods, <\/i>23<\/b>, 585\u2013595 (2026).<\/span><\/p>\n

Zhang L, Liu X, Si C, Hou X, Hu X, Chen Y, Hu J<\/u>, Turch C, Shan B, Zhang Y<\/span>.<\/i> <\/span><\/span>IDE-mediated GLP-1 degradation as the basis for designing long-acting and CNS-stable GLP-1 receptor agonists<\/b>. <\/span><\/span>Science Advance<\/i>,<\/i> <\/span><\/span>12<\/b>, eaeh4670 (2026).<\/span><\/span><\/span><\/p>\n

Li T, Can X, Zhou F, Li X, Ma W, Zhang X, Zhong H, Xu B, Chu M, Jia X, Ding K, Shen X, Liu Y, Zhao Y, Zhang Z, Hu J<\/u>, Hong YK, Claesson-Welsh L, He Y<\/span>.<\/i> <\/span><\/span>Endothelial VEGFR2 insufficiency promotes the transition of lymphatic to hematopoietic transcriptional programs<\/b>. <\/span><\/span>Angiogenesis<\/i>,<\/i> <\/span><\/span>29<\/b>, 51 (2026).<\/span><\/span><\/span><\/p>\n

Mao Y, Gon\u00e7alves A, Rinck L, Hogarth M, Hofsetz G, Kamiyama M, Wu C, Hu J<\/u>, Singhal M<\/span><\/span>.<\/i> <\/span><\/span>Proliferation dynamics of organotypic vascular endothelium during aging<\/b>. <\/span><\/span>npj Cardiovasc. Heal<\/i>.<\/i> <\/span><\/span>3<\/b>, 46 (2026). <\/span><\/span><\/span><\/p>\n

2025<\/p>\n

He K*, Dong X*, Yang T*, Li Z, Liu Y, He J, Wu M, Wei-Zhang S, Kayaker P, Chi B, Yao X, Zhang L, Zhou W, Xu H, Wei J, Liu Q, Hu J<\/u>#, Wang X#, Yan H#<\/span>. <\/span>Smoking aggravates neovascular age-related macular degeneration via Sema4D-PlexinB1 axis-mediated activation of pericytes<\/b>. <\/span>Nature Communications,<\/i> 16(1):2821, (2025).<\/span><\/p>\n

Lei Y, Hu JD, Zhao J, Liu QY, Zhang W, Wu F, Liu Y, Ren H, Qin X, Wu X, Gao F, <\/span>Hu J<\/u>, Quyang K, Liu Q, Zheng X, Shi L, Wang X<\/span>.<\/i> <\/span>Deubiquitinase USP9X controls Wnt signaling for CNS vascular formation and barrier maintenance<\/b>. <\/span>Dev. Cell. <\/i> <\/span>60<\/b>, 1618-1635.e7 (2025).<\/span><\/p>\n

Zhou C, Shan S, Wen L, Liu D, Shan C, Jin X, Zhou Z, Li H, Li J, Wang L, Bu J, Li B, Huang W, Hu J<\/u>, Guo H, Wei W. Immunological and pathological characteristics of brain parenchymal and leptomeningeal metastases from non-small cell lung cancer<\/b>. Cell Discov.<\/i> 11<\/b>, 72 (2025).<\/span><\/p>\n

2024<\/p>\n

Ma N, Wu F, Wu Z, Wang L, Li B, Liu Y, Dong X, Hu J<\/u>, Fang X, Zhang H, Ai D, Zhou J#, Wang X#. Kindlin-2 phase separation in response to flow controls vascular stability<\/b>. Circulation Research,<\/i> (2024).<\/p>\n

Zhu J*, Yang W*#, Ma J*, He H*, Liu Z*, Zhu X, He X, He J, Chan Z, Jin X, Wang X, He K, Wei W#, Hu J<\/u>#. Pericyte Signaling via soluble guanylate cyclase shapes the vascular niche and microenvironment of tumors<\/b>. The EMBO Journal,<\/i> 43(8): 1519, (2024).<\/p>\n

Lei Y*, Liu Q, Chen B, Wu F, Li Y, Dong X, Ma N, Wu Z, Zhu Y, Wang L, Fu Y, Liu Y, Song Y, Du M, Zhang H, Zhu J, Lyons T, Wang T, Hu J<\/u>, Xu H, Chen M, Yan H#, Wang X#. Protein O-GlcNacylation coupled to Hippo signaling drives vascular dysfunction in diabetic retinopathy<\/b>. Nature Communications<\/i>, 15(1):9334, (2024). <\/p>\n

Zhang T, Fu W, Zhang H, Li J, Xing B, Cai Y, Zhang M, Liu X, Qi C, Qian L, Hu X, Zhu H, Yang S, Zhang M, Liu J, Li G, Li Y, Xiang R, Qi Z, Hu J<\/u>, Li Y, Zhou C, Wang Q, Jin X, Pang R, Zhu ZJ, Shan B, Yuan J.<\/i> Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression<\/b>. Nat. Cell Biol.<\/i> 26<\/b>, 2099\u20132114 (2024).<\/span><\/p>\n


<\/p>\n

2023<\/p>\n

Zhao X, Zhang Z, Zhu Q, Luo Y, Ye Q, Shi S, He X, Zhu J, Zhang D, Xia W, Zhang Y, Jiang L, Cui L, Ye Y, Xiang Y, Hu J<\/u>, Zhang J, Lin C. Modeling human ectopic pregnancies with trophoblast and vascular organoids<\/b>. Cell Reports,<\/i> 42(6):112546, (2023).<\/p>\n

He H*, Yang W*, Su N*, Zhang C, Dai J, Han F, Singhal M, Bai W, Zhu X, Zhu J, Liu Z, Xia W, Liu X, Zhang C, Jiang K, Huang W, Chen D, Wang Z, He X, Kirchhoff F, Li Z, Liu C, Huan J, Wang X, Wei W, Wang J, Augustin H, Hu J<\/u>. Activating NO-sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury<\/b>. Journal of Experimental Medicine<\/i>, 220(2):e20211422, (2023).<\/p>\n

2022<\/p>\n

Zhang C, He H, Dai J, Li Y, He J, Yang W, Dai J, Han F, Kong W, Wang X, Zheng X, Pan W, Chen Z, Singhal M, Zhang Y, Guo F#, Hu J<\/u>#. KANK4 promotes arteriogenesis by potentiating VEGFR2 signaling in a TALIN-1\u2013dependent manner<\/b>. Arteriosclerosis, Thrombosis, and Vascular Biology<\/i>, 42:772-788, (2022).<\/p>\n

Zhu S, Rao X, Qian Y, Chen J, Song R, Yan H, Yang X, Hu J<\/u>, Wang X, Han Z, Liu R, Wong J, McCaughan G, Zheng X. Liver Endothelial Heg regulates vascular\/biliary network patterning and metabolic zonation via Wnt signaling<\/b>. Cellular and Molecular Gastroenterology and Hepatology<\/i>, 6:1757-1783, (2022).<\/p>\n

2021<\/p>\n

Singhal M, Gengenbacher M, Abdul Pari AA, Kamiyama M, Hai L, Kuhn BJ, Kallenberg DM, Kulkarni SR, Camilli C, Preuss S, Leuchs B, Mogler C, Espinet E, Besemfelder E, Heide D, Heikenwalder M, Sprick M, Trumpp A, Krijgsveld J, Schlesner M, Hu J<\/u>, Moss S, Greenwood J, Augustin H. Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis<\/b>. Science Translational Medicine<\/i>, 13 (609), eabe6805, (2021).<\/p>\n

Yang W*, He H*, Wang T, Su N, Zhang F, Jiang K, Zhu J, Zhang C, Niu K, Wang L, Yuan X, Liu N, Li L, Wei W, Hu J<\/u>. Single-cell transcriptomic analysis reveals a hepatic stellate cell-activation roadmap and myofibroblast origin during liver fibrosis<\/b>. Hepatology<\/i>, 74: 2774\u20132790, (2021).<\/p>\n

Shan H, Liu J, Shen J, Dai J, Xu G, Lu K, Han C, Wang Y, Xu X, Tong Y, Xiang H, Ai Z, Zhuang G, Hu J<\/u>, Zhang Z, Li Y, Pan L, Tan L. Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2<\/b>. Cell Chemical Biology<\/i>, 28: 855\u2013865, (2021).<\/p>\n

Gengenbacher N*, Singhal M*, Mogler C, Hai L, Milde L, Pari A, Besemfelder E, Fricke C, Baumann D, Gehrs S, Utikal J, Felcht M, Hu J<\/u>, Schlesner M, Offringa M, Chintharlapalli S, Augustin H. Timed Ang2-targeted therapy identifies the Angiopoietin-Tie pathway as key regulator of fatal lymphogenous metastasis<\/b>. Cancer Discovery<\/i>, 11: 424\u2013445, (2021).<\/p>\n

2020<\/p>\n

Dai J, Zhang C, Guo L, He H, Kai J, Huang Y, Zhang X, Zhang H, Wei W, Zhang Y, Lu L#, Hu J<\/u>#. A necroptotic-independent function of MLKL in regulating endothelial cell adhesion molecule expression<\/b>. Cell Death and Disease<\/i>, 11: 282, (2020). (#, co-corresponding authors).<\/p>\n

Jiang H, Zhang L, Liu X, Sun W, Kato K, Chen C, Li X, Li T, Sun Z, Han W, Zhang H, Xiao Q, Yang Z, Hu J<\/u>, Qin Z, Adams R, Gao X, He Y. Angiocrine FSTL1 (follistatin-like protein 1) insufficiency leads to atrial and venous wall fibrosis via SMAD3 activation<\/b>. Arteriosclerosis, Thrombosis, and Vascular Biology<\/i>, 40: 958\u2013972, (2020).<\/p>\n

2018<\/p>\n

Singhal M*, Liu X*, Inverso D, Jiang K, Dai J, He H, Bartels S, Li W, Abdul Pari AA, Gengenbacher N, Besemfelder E, Hui L, Augustin H#, Hu J<\/u>#. Endothelial cell fitness dictates the source of regenerating liver vasculature<\/b>. Journal of Experimental Medicine<\/i>, 215: 2497\u20132598, (2018). ( #, co-corresponding authors).<\/p>\n

Hu C*, Li W*, Tian F, Jiang K, Liu X, Cen J, He Q, Qiu Z, Keenest Y, Wang Z, Zhang H, Ji Y#, Hu J<\/u>#, Hui L#. Arid1a regulates response to anti-angiogenic therapy in advanced hepatocellular carcinoma<\/b>. Journal of Hepatology<\/i>, 68: 465\u2013475, (2018). (#, <\/span>co-corresponding authors).<\/span><\/p>\n

Guo L, Yang W, Huang Q, Qiang J, Hart JR, Wang W, Hu J<\/u>, Zhu J, Liu N, Zhang Y. Selenocysteine-specific mass spectrometry reveals tissue-distinct selenoproteomes and candidate selenoproteins<\/b>. Cell Chemical Biology<\/i>, 25: 1\u20139, (2018).<\/p>\n

2017<\/p>\n

Manavski Y, Abel T, Hu J<\/u>, Kleinl\u00fctzum D, Buchholz CJ, Belz C, Augustin H, Boon R, Dimmeler S. Endothelial transcription factor KLF2 negatively regulates liver regeneration via induction of activin A<\/b>. Proceedings of the National Academy of Sciences<\/i>, 114: 3993\u20133998, (2017).<\/p>\n

Teichert M, Milde L, Holm A, Stanicek L, Gengenbacher N, Savant S, Ruckdeschel T, Hasanov Z, Srivastava K, Hu J<\/u>, Hertel S, Bartol A, Schlereth K, Augustin H. Pericyte-expressed Tie2 controls angiogenesis and vessel maturation<\/b>. Nature Communications<\/i>, 8, 16106, (2017).<\/p>\n

2016<\/p>\n

SY, Lee JH, Kim SJ, Kim HC, Kim S, Kim SH, Kim C, Nakaoka Y, He Y, Augustin H, Hu J<\/u>, Song PH, Kim YI, Kim P, Kim I, Koh GY. Amelioration of sepsis by TIE2 activation-induced vascular protection<\/b>. Science Translational Medicine<\/i>, 8, 335ra55, (2016).<\/p>\n

2015<\/p>\n

Yang W-J*, Hu J<\/u>*, Uemura A, Tetzlaff F, Augustin HG, Fischer A. Semaphorin-3C signals through Neuropilin-1 and PlexinD1 receptors to inhibit pathological angiogenesis<\/b>. EMBO Molecular Medicine<\/i>, 7: 1267\u20131284, (2015). (*, co-first authors).<\/p>\n

Mogler C, Wieland M, K\u00f6nig C, Hu J<\/u>, Runge A, Korn C, Besemfelder E, Breitkopf-Heinlein K, Komljenovic D, Dooley S, Schirmacher P, Longerich T, Augustin H. Hepatic stellate cell-expressed endosialin balances fibrogenesis and hepatocyte proliferation during liver damage<\/b>. EMBO Molecular Medicine<\/i>, 7: 332\u2013338, (2015).<\/p>\n

Savant S, La Porta S, Budnik A, Busch K, Hu J<\/u>, Tisch N, Korn C, Valls AF, Benest AV, Terhardt D, Qu X, Adams R, Baldwin S, Ruiz de Almodovar C, Rodewald H, Augustin H. The orphan receptor Tie1 controls angiogenesis and vascular remodeling by differentially regulating Tie2 in tip and stalk cells<\/b>. Cell Reports<\/i>, 12, 1761\u20131773, (2015).<\/p>\n

2014<\/p>\n

Hu J<\/span>*<\/span><\/u>,<\/u> Srivastava S<\/span>*<\/span>, Wieland M, Runge A, Mogler C, Besemfelder E, Terhardt D, Vogel M, Cao L, Korn C, Bartels S, Thomas M, Augustin HG.<\/i> Endothelial cell-derived angiopoietin-2 controls liver regeneration as a spatiotemporal rheostat<\/b>. Science, <\/i>343<\/b>, 416\u2013419 (2014). <\/span>(*, co-first authors).<\/span><\/p>\n

Srivastava K*<\/span>, Hu J*<\/u><\/span>, Korn C, Savant S, Teichert M, Kapel S, Jugold M, Besemfelder E, Thomas M, Pasparakis M, Augustin HG.<\/span> Postsurgical Adjuvant Tumor Therapy by Combining Anti-Angiopoietin-2 and Metronomic Chemotherapy Limits Metastatic Growth<\/b>. <\/span>Cancer Cell,<\/i> <\/span>26<\/b>, 880\u2013895 (2014). <\/span>(*, co-first authors).<\/span><\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

2026 Fang Y, Shen Q, Lin Y, Zhu J, Zhu X, Huang R, Wu Y, Shen F, Li Q, Zheng G, Zhang Z, Chu Q#, Hu J#, Shen J#. PARPi combining nanoparticle LIN28B siRNA for the management of malignant ascites. Advanced Science, e10547, (2026). Luo M, Kou T, Yin Y, Zhou S, Zhu X, Zeng X, …<\/p>\n

Publications<\/span> Read More »<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-global-header-display":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","footnotes":""},"_links":{"self":[{"href":"http:\/\/www.junhaohulab.cn\/index.php\/wp-json\/wp\/v2\/pages\/2"}],"collection":[{"href":"http:\/\/www.junhaohulab.cn\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.junhaohulab.cn\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.junhaohulab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.junhaohulab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=2"}],"version-history":[{"count":184,"href":"http:\/\/www.junhaohulab.cn\/index.php\/wp-json\/wp\/v2\/pages\/2\/revisions"}],"predecessor-version":[{"id":1018,"href":"http:\/\/www.junhaohulab.cn\/index.php\/wp-json\/wp\/v2\/pages\/2\/revisions\/1018"}],"wp:attachment":[{"href":"http:\/\/www.junhaohulab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=2"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}